Synchronous Neuronal Activity Is a Signal for Axonal Sprouting after Cortical Lesions in the Adult
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چکیده
منابع مشابه
Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult.
The ability of the adult brain to form new connections in areas denervated by a lesion (axonal sprouting) is more widespread than previously thought, but mechanisms remain unknown. We have previously demonstrated an unexpected, robust axonal sprouting of contralateral corticostriatal neurons into the denervated striatum after ischemic cortical lesions. We now take advantage of marked difference...
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Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use of the affected limb and is associated with sprouting of new connections, a process that is sharply confined in the adult brain. We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. Blockade of ephrin-A5 s...
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Acknowledgements Thank you to all the members of the Jones' Lab, who have guided, encouraged, and supported me during my time in the lab. Special thanks go to Dr. Theresa Jones, for being so patient and understanding during this process, and for all the advice and direction she gave. Also to Dr. Stephanie Jefferson and Dr. Rachel Allred, for all their hard work in helping with the design, execu...
متن کاملSprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration.
After an incomplete spinal cord injury (SCI), partial recovery of locomotion is accomplished with time. Previous studies have established a functional link between extension of axon collaterals from spared spinal tracts and locomotor recovery after SCI, but the tissular signals triggering collateral sprouting have not been identified. Here, we investigated whether axonal degeneration after SCI ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2002
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.22-14-06062.2002